Pharmacogenetics
(PGx)
Eliminate the guesswork…
In the US there are over 2.2 million severe drug reactions
Each Year
You don't know what you don't know
What is Pharmacogenetics (PGx)??
Pharmacogenomic is the study of how genes affect a person’s response to drugs. The science of determining genetic differences to predict whether a medication will be effective for a particular person and to prevent adverse side effects is known as Pharmacogenetics (PGx). People can respond differently to the same medications and doses, or experience different side effects because of the genes we have inherited. Therefore, these differences in genetic make-up can explain why a drug that is effective for some may be less effective for others or why a drug that is safe for one person may be less safe for another person.
Why Pharmacogenetics?
Our PGx testing allows a person to have prescriptions tailored to their individual needs. By analyzing the genes that produce specific drug targets or enzymes that metabolize a medication, a dose can be lowered, a different drug can be prescribed, or drug-drug interactions can be prevented.
What we DO know…
Pharmacogenetic testing provides evidence-based, actionable data that creates a personalized perspective for clinicians. This will help healthcare providers tailor any treatment plans to patients' specific needs and provides insight into unexpected drug monitoring results. The advancement of genetic research has led the healthcare community to have a greater understanding and the importance of genetics in all disease states. As a result, this has created a much higher demand for pharmacogenetic testing.
Statistics on Adverse Drug Events:
check_circle82% of American adults take at least one medication and 29% take five or more. (CDC).
check_circleAdverse Drug Events (ADE) cause over 700,000 emergency department visits each year. (CDC).
check_circleNearly 120,000 patients each year need to be hospitalized for further treatment (CDC).
check_circleOver 100,000 people die each year due to adverse drug events (FDA).
check_circle4th leading cause of death, ahead of pulmonary disease, diabetes, AIDS, pneumonia, accidents and automobile deaths (FDA).
check_circleADEs cause injuries or death in 1 of 5 hospital patients. (New England Journal of Medicine).
check_circle$3.5 billion is spent on extra medical costs dues to ADEs annually (CDC).
check_circle75% of the US population does not metabolize medications “normally” (FDA)
check_circleApproximately 2.2 million adverse drug events occur annually in the U.S. (CDC)
check_circleThe FDA lists more than 100 drugs that have a Black box warning suggesting a PGX be performed prior to taking (FDA)
check_circle1/3 of all clinically significant drug interactions are caused by drug/gene interactions, not drug/drug interactions (CDC)
check_circleADVERSE DRUG EVENTS ARE PREVENTABLE
SUPREME PGX - Comprehensive Gene List
ABCB1
ABCG2
ADRA2A
ADRB2
ANKK1
APOE
C11ORF65
COMT
CYP1A2
CYP2B6
CYP2C19
CYP2C8
CYP2C9
CYP2D6
CYP3A4
CYP3A5
CYP4F2
DPYD
DRD2
EPHX1
FACTOR 2
FACTOR V
GRIK4
HTR1A
HTR2A
HTR2C
ITGB3
MTHFR
NUDT15
OPRM1
SLC6A2
SLCO1B1
TPMT
UGT2B15
VKORC1
